Don Tillman, a professor of genetics, has a brilliant scientific mind, but social situations confound him. He’s never had a second date. And so, in the evidence-based manner in which he approaches all things, he embarks upon the Wife Project: a sixteen-page questionnaire to find the perfect partner. Then in walks Rosie Jarman. Rosie is on a quest of her own. She’s looking for her biological father, a search that a certain genetics expert might just be able to help her with. Soon Don puts the Wife Project on the back burner in order to help Rosie pursue the Father Project. As their unlikely relationship blooms, Don realizes that love doesn’t always add up on paper.